Ketamine Produces Anesthesia and Analgesia in Miniature Pigs Via NO-cGMP Signaling Pathway
نویسندگان
چکیده
منابع مشابه
NO mobilizes intracellular Zn2+ via cGMP/PKG signaling pathway and prevents mitochondrial oxidant damage in cardiomyocytes.
OBJECTIVE Our aim was to determine if NO prevents mitochondrial oxidant damage by mobilizing intracellular free zinc (Zn(2+)). METHODS Zn(2+) levels were determined by imaging enzymatically isolated adult rat cardiomyocytes loaded with Newport Green DCF. Mitochondrial membrane potential (DeltaPsi(m)) was assessed by imaging cardiomyocytes loaded with tetramethylrhodamine ethyl ester (TMRE). ...
متن کاملRole of L-arginine/NO/cGMP/KATP channel signaling pathway in the central and peripheral antinociceptive effect of thymoquinone in rats
Objective(s): Growing evidence demonstrates that L-arginine/NO/cGMP/KATP channel pathway has a modulatory role in pain perception. Previous studies have shown that thymoquinone exerts antinociceptive effects; however, the mechanisms underlying antinociception induced by thymoquinone have not been fully clarified. The aim of the present study was to evaluate the role of L-arginine/NO/cGMP/KATP c...
متن کاملPropofol produces preventive analgesia via GluN2B-containing NMDA receptor/ERK1/2 signaling pathway in a rat model of inflammatory pain
Abstract Propofol, an intravenous anesthetic, has been shown to offer superior analgesic effect clinically. Whether propofol has preventive analgesic property remains unexplored. The present study investigated the antinociceptive effect of propofol and underlying molecular and cellular mechanisms via pre-emptive administration in a formalin-induced inflammatory pain model in rats. Male adult Sp...
متن کاملA Rac-cGMP Signaling Pathway
The small GTPase Rac and the second messenger cGMP (guanosine 3',5'-cyclic monophosphate) are critical regulators of diverse cell functions. When activated by extracellular signals via membrane signaling receptors, Rac executes its functions through engaging downstream effectors such as p21-activated kinase (PAK), a serine/threonine protein kinase. However, the molecular mechanism by which memb...
متن کاملEpidural Analgesia with Bupivacaine, Ketamine, and the Combination of Bupivacaine and Ketamine in Sheep
Objective- To evaluate the effects of bupivacaine (B), ketamine (K), and a combination of bupivacaine and ketamine (BK) after lumbosacral epidural analgesia in sheep. Design- Experimental study. Animals- Nine healthy male and non-pregnant female Iranian Chall sheep with mean body weight of 38.9 ± 15.1 kg. Procedures- Animals were selected randomly and three treatments administered. The ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Pakistan Veterinary Journal
سال: 2019
ISSN: 0253-8318,2074-7764
DOI: 10.29261/pakvetj/2018.107